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MMP-2/MMP-3 Inhibitor III, PD166793-CAS 199850-67-4-Calbiochem
产品编号: | 4084110 |
规格: | The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
CAS NO: | 199850-67-4 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
199850-67-4
MMP-2/MMP-3 Inhibitor III, PD166793-CAS 199850-67-4-Calbiochem
(S)-2-(4'-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
基本信息
Empirical Formula【经验(实验)分子式】 | C17H18BrNO4S |
Molecular weight | 412.30 |
General description【一般描述】 | A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively Product does not compete with ATP. Reversible: no Primary Target MMP-2, -3, and -13 |
Warning【警告】 | Toxicity: Irritant (B) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Other Notes【其他说明】 | Paolocci, N., et al. 2006. J. Pharm. Exp. Ther.317, 506. Zhou, Y.P., et al. 2005. Diabetes54, 2612. Peterson, J.T., et al. 2001. Circulation103, 2303. Spinale, F.G., et al. 1999. Circ. Res.85, 364. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (TLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 40 mg/mL ethanol: 40 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |