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MG-115-CAS 133407-86-0-Calbiochem

产品编号:4084108
规格:Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
CAS NO:133407-86-0
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40841085 MG3350
产品别名

133407-86-0

MG-115-CAS 133407-86-0-Calbiochem

Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII

基本信息
Empirical Formula【经验(实验)分子式】
C25H39N3O5
Molecular weight
461.59
General description【一般描述】
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.
Biochem/physiol Actions【生化/生理作用】
Product does not compete with ATP.
Target Ki: 21 nM and 35 nM for 20S and 26S proteasome, respectively
Cell permeable: no
Reversible: yes
Primary Target
20S proteasome
Warning【警告】
Toxicity: Standard Handling (A)
Sequence【序列】
Z-Leu-Leu-Nva-CHO
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
white
solubility【溶解性】
DMSO: 50 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
5 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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