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MG-115-CAS 133407-86-0-Calbiochem
产品编号: | 4084108 |
规格: | Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). |
CAS NO: | 133407-86-0 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084108 | 5 MG | 3350 |
产品别名
133407-86-0
MG-115-CAS 133407-86-0-Calbiochem
Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
基本信息
Empirical Formula【经验(实验)分子式】 | C25H39N3O5 |
Molecular weight | 461.59 |
General description【一般描述】 | Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells. |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Target Ki: 21 nM and 35 nM for 20S and 26S proteasome, respectively Cell permeable: no Reversible: yes Primary Target 20S proteasome |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | Z-Leu-Leu-Nva-CHO |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893. Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280. Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761. Vinitsky, A., et al. 1992. Biochemistry 31, 9421. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥90% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | white |
solubility【溶解性】 | DMSO: 50 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |