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Kir2.1 Inhibitor, ML133-CAS 185669-79-8-Calbiochem

产品编号:4084096
规格:The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.
CAS NO:185669-79-8
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40840965 MG2150
产品别名

185669-79-8

Kir2.1 Inhibitor, ML133-CAS 185669-79-8-Calbiochem

Inward rectifier potassium channel blocker, ML133

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C19H19NO
Molecular weight
277.36
MDL number
MFCD01469095
General description【一般描述】
A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 >300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Lindsley, C.W., et al. 2011. ACS Chem. Biol.6, 845.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
white
solubility【溶解性】
DMSO: 10 mg/mL, clear, colorless
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
SMILES string
COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
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