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JAK3 Inhibitor II-CAS 211555-04-3-Calbiochem
产品编号: | 4084090 |
规格: | The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
CAS NO: | 211555-04-3 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084090 | 5 MG | 3730 |
产品别名
211555-04-3
JAK3 Inhibitor II-CAS 211555-04-3-Calbiochem
4-[(3'-Bromo-4'-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
基本信息
Empirical Formula【经验(实验)分子式】 | C16H14BrN3O3 |
Molecular weight | 376.20 |
General description【一般描述】 | A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration. A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target JAK-3 Product competes with ATP. Target IC50: 5.6 µM against JAK3 Reversible: yes |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Ghosh, S., et al. 2001. Acta Crystallogr. C.57, 76. Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569. Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742. Narla, R.K., et al. 1998. Clin Cancer Res.4, 2463. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | pale yellow |
solubility【溶解性】 | DMSO: 100 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |