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JAK3 Inhibitor I-CAS 202475-60-3-Calbiochem

产品编号:4084089
规格:The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
CAS NO:202475-60-3
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40840895 MG3010
产品别名

202475-60-3

JAK3 Inhibitor I-CAS 202475-60-3-Calbiochem

4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131

基本信息
Empirical Formula【经验(实验)分子式】
C16H15N3O3
Molecular weight
297.31
General description【一般描述】
A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
Janus family kinase 3
Target IC50: 78 µM against Janus family kinase 3
Product competes with ATP.
Reversible: yes
Warning【警告】
Toxicity: Standard Handling (A)
Other Notes【其他说明】
Tibbles, H.E., et al. 2001. J. Biol. Chem.276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res.5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
white to off-white
solubility【溶解性】
DMSO: 50 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
5 mg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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