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JAK2 Inhibitor IV-CAS 1110502-30-1-Calbiochem

产品编号:4084088
规格:The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
CAS NO:1110502-30-1
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40840885 MG5110
产品别名

1110502-30-1

JAK2 Inhibitor IV-CAS 1110502-30-1-Calbiochem

3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole

基本信息
Empirical Formula【经验(实验)分子式】
C17H20N4O2S
Molecular weight
344.43
General description【一般描述】
An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
Warning【警告】
Toxicity: Standard Handling (A)
Other Notes【其他说明】
Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
pale yellow
solubility【溶解性】
ethanol: 3 mg/mL
DMSO: 5 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
packaging【包装】
5 mg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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