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Interleukin-10, Human, Recombinant, S. frugiperda
产品别名
Interleukin-10, Human, Recombinant, S. frugiperda
rhIL-1αrhIL-1βrhIL-10
产品性质
Assay【测定】 | ≥95% (SDS-PAGE) |
Quality Level【质量水平】 | 100 |
form【形式】 | lyophilized |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze |
impurities【杂质】 | <100 pg/μg Endotoxin (pg/μg IL-10) |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −70℃ |
packaging【包装】 | 5 μg in Plastic ampoule |
基本信息
General description【一般描述】 | Recombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Human IL-10 has cross-species reactivity and is active in mouse cell lines. Recombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Blocks lipopolysaccharide induction of MMP-2 and MMP-9. Known to reduce neuronal degeneration following CNS injury by blocking glutamate-induced caspase-3 activation. Human IL-10 is also active on murine cell lines. |
Biochem/physiol Actions【生化/生理作用】 | ED₅₀ = 0.2-1 ng/ml as measured in a cell proliferation assay using a mouse mast cell line, MC/9. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Physical form【外形】 | Carrier-free. |
Reconstitution【重悬】 | Reconstitute in sterile water or buffer to a final concentration of 0.1-1 mg/ml as stock solution. Further dilute in buffer such as PBS, 1% BSA. Following reconstitution, aliquot and freeze -70°C. Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions. |
Other Notes【其他说明】 | Bachis, A., et al. 2001. J. Neurosci.21, 3104. Fortunato, S.J., et al. 2001. Obstet. Gynecol.98, 284. Fleming, S.D., et al. 1996. J. Immunol. 156, 1143. Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305. Niro, H., et al. 1994. Int. Immunol. 6, 661. Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165. Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |