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Integrin αvβ3 Antagonist, P11-Calbiochem
产品编号: | 4084084 |
规格: | The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3. |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Integrin αvβ3 Antagonist, P11-Calbiochem
HSDVHK-NH2, HSDVHK
基本信息
Empirical Formula【经验(实验)分子式】 | C30H51N12O93 · 3C2HF3O2 |
Molecular weight | 2409.82 |
General description【一般描述】 | A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Physical form【外形】 | Supplied as a trifluoracetate salt. |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Bang, J., et al. 2011. Mol Cell Proteomics10, M110. Choi, Y., et al. 2010. Proteomics10, 72. Lee, Y., et al. 2004. J. Biomol. Screen.9, 687. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | white |
solubility【溶解性】 | water: 100 mg/mL |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |