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InSolution Simvastatin, Sodium Salt-Calbiochem

产品编号:4084081
规格:Carboxylate form of Simvastatin that is active in whole cells and in cell-free assays.
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40840815 MG3730
产品别名

InSolution Simvastatin, Sodium Salt-Calbiochem

L-Type Calcium Channel Blocker VI

基本信息
Empirical Formula【经验(实验)分子式】
C25H39O6 · Na
Molecular weight
458.56
General description【一般描述】
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Reversible: yes
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-70°C).
Other Notes【其他说明】
Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
liquid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
avoid repeated freeze/thaw cycles
protect from light
shipped in【运输】
ambient
storage temp.【储存温度】
−70℃
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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