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InSolution Simvastatin, Sodium Salt-Calbiochem
产品编号: | 4084081 |
规格: | Carboxylate form of Simvastatin that is active in whole cells and in cell-free assays. |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
InSolution Simvastatin, Sodium Salt-Calbiochem
L-Type Calcium Channel Blocker VI
基本信息
Empirical Formula【经验(实验)分子式】 | C25H39O6 · Na |
Molecular weight | 458.56 |
General description【一般描述】 | Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available. Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: yes |
Warning【警告】 | Toxicity: Irritant (B) |
Physical form【外形】 | A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). |
Other Notes【其他说明】 | Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016. Keyomarsi, K., et al. 1991. Cancer Res.51, 3602. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −70℃ |
packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |