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InSolution CFTR Inhibitor II, GlyH-101-CAS 328541-79-3-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084073 | 5 MG | 3240 |
产品别名
328541-79-3
InSolution CFTR Inhibitor II, GlyH-101-CAS 328541-79-3-Calbiochem
N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
基本信息
Empirical Formula【经验(实验)分子式】 | C19H15Br2N3O3 |
Molecular weight | 493.15 |
General description【一般描述】 | A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: yes |
Warning【警告】 | Toxicity: Irritant (B) |
Physical form【外形】 | A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | liquid |
potency【效能】 | 4.3 μM Ki |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |
Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |