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InSolution CFTR Inhibitor II, GlyH-101-CAS 328541-79-3-Calbiochem

产品编号:4084073
CAS NO:328541-79-3
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40840735 MG3240
产品别名

328541-79-3

InSolution CFTR Inhibitor II, GlyH-101-CAS 328541-79-3-Calbiochem

N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

基本信息
Empirical Formula【经验(实验)分子式】
C19H15Br2N3O3
Molecular weight
493.15
General description【一般描述】
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Reversible: yes
Warning【警告】
Toxicity: Irritant (B)
Physical form【外形】
A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
liquid
potency【效能】
4.3 μM Ki
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F - (refers to pure substance)
Flash Point(C)【闪点(C)】
87 ℃ - (refers to pure substance)
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