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InSolution ALLN-CAS 110044-82-1-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084071 | 5 MG | 1940 |
产品别名
110044-82-1
InSolution ALLN-CAS 110044-82-1-Calbiochem
Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
基本信息
Empirical Formula【经验(实验)分子式】 | C20H37N3O4 |
Molecular weight | 383.53 |
MDL number | MFCD00065505 |
General description【一般描述】 | A 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target calpain 1 Target Ki: 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively Product does not compete with ATP. Reversible: no |
Warning【警告】 | Toxicity: Flammable (J) |
Physical form【外形】 | A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO. |
Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
Other Notes【其他说明】 | Milligan, S.A., et al. 1996. Arch. Biochem. Biophys.335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721. Squier, M.K., et al. 1994. J. Cell Physiol.159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res.609, 67. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solution |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | clear colorless |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
InChI | 1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1 |
InChI key | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |