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InSolution ALLN-CAS 110044-82-1-Calbiochem

产品编号:4084071
CAS NO:110044-82-1
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40840715 MG1940
产品别名

110044-82-1

InSolution ALLN-CAS 110044-82-1-Calbiochem

Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V

基本信息
Empirical Formula【经验(实验)分子式】
C20H37N3O4
Molecular weight
383.53
MDL number
MFCD00065505
General description【一般描述】
A 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
calpain 1
Target Ki: 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Flammable (J)
Physical form【外形】
A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-20°C).
Other Notes【其他说明】
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys.335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol.159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res.609, 67.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solution
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
clear colorless
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
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