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IC261-CAS 186611-52-9-Calbiochem

产品编号:4084067
规格:A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes.
CAS NO:186611-52-9
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40840675 MG3010
产品别名

186611-52-9

IC261-CAS 186611-52-9-Calbiochem

3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI

基本信息
Empirical Formula【经验(实验)分子式】
C18H17NO4
Molecular weight
311.33
MDL number
MFCD00118156
General description【一般描述】
A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 µM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34cdc2, and p55fyn (IC50s >100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
CK1δ
Product competes with ATP.
Reversible: yes
Target IC50: 0.7-1.3 µM, 0.6-1.4 µM, against CK1δ and CK1ε isozymes, respectively
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.
Other Notes【其他说明】
Behrend, L., et al. 2000. Oncogene19, 5303.
Mashhoon, N., et al. 2000. J. Biol. Chem.275, 20052.
Knippschild, U., et al. 1997. Oncogene15, 1727.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (sum of two isomers, HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
yellow
solubility【溶解性】
DMSO: 100 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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