Caspase-1 Inhibitor II-CAS 178603-78-6-Calbiochem

C₂₄H₃₃ClN₄O₈

540.99

MFCD00237124

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
A cell-permeable and irreversible inhibitor of caspase-1 (K_i = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Cell permeable: yes
Target K_i: 760 pM against caspase-1
Product does not compete with ATP.
Reversible: no
Primary Target
caspase-1

Toxicity: Standard Handling (A)

Ac-Tyr-Val-Ala-Asp-CMK

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.
Enari, M., et al. 1995. Nature375, 78.
Walker, N.P.C., et al. 1994. Cell78, 343.
Thornberry, N., et al. 1992. Nature356, 768.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated

white

DMSO: 5 mg/mL

ambient

−20℃

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 3