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AY 9944-CAS 366-93-8-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083998 | 5 MG | 3280 |
产品别名
366-93-8
AY 9944-CAS 366-93-8-Calbiochem
trans-1,4- bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H28Cl2N2 · 2HCl |
| Molecular weight | 464.30 |
| General description【一般描述】 | A cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target 7-dehydrocholesterol reductase (δ7-sterol reductase) Target IC50: 13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Gofflot, F., et al. 2001. Dev. Dyn.220, 99. Cooper, M.K., et al. 1998. Science280, 1603. Incardona, J.P., et al. 1998. Development125, 3553. Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899. Yoshida, Y. 1985. J. Biochem.98, 1669. Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun.15, 455. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 20 mg/mL water: 20 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H |
| InChI key | NRVIEWRSGDDWHP-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
