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E-4031-CAS 113558-89-7-Calbiochem
| 产品编号： | 4083832 |
| 规格： | A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM). |
| CAS NO： | 113558-89-7 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
113558-89-7
E-4031-CAS 113558-89-7-Calbiochem
4'-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H27N3O3S · 2HCl · 2H2O |
| Molecular weight | 510.47 |
| General description【一般描述】 | A potent and selective inhibitor of the inactivating inward-rectifying potassium current (IK,IR) (IC50 = 10 nM). In inside-out patches, E-4031 also blocks ATP sensitive K+ channel (EC50 = 31 µM). A specific blocker of cardiac HERG channels (IC50 = 7.7 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC50 = 7.7 nM). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Inhibitor of the rapid type of inactivating inward-rectifying K+ current Product does not compete with ATP. Reversible: no Target IC50: 10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Ficker, E., et al. 2000. Am. J. Physiol.279, H1748. Ono, K., et al. 2000. J. Physiol. (London)524 (Pt. 1), 51. Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol.22, 67. Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37. Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135. Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1. West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther.2, 205. West, P.D., et al. 1996. Pharmacol. Toxicol.78, 89. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: 50 mg/mL water: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C21H27N3O3S/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23H,10-15H2,1-2H3 |
| InChI key | SRUISGSHWFJION-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
