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Tubulin Polymerization Inhibitor II
| 产品编号： | 4083772 |
| 规格： | The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications. |
| CAS NO： | 1151995-69-5 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
1151995-69-5
Tubulin Polymerization Inhibitor II
(E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H19NO5 |
| Molecular weight | 341.36 |
| General description【一般描述】 | A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin Product does not compete with ATP. Reversible: no Primary Target Purified porcine brain tubulin |
| Warning【警告】 | Toxicity: Harmful (C) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492. Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
