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Cdk9 Inhibitor II-CAS 140651-18-9-Calbiochem
| 产品编号： | 4083765 |
| 规格： | The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 140651-18-9 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
140651-18-9
Cdk9 Inhibitor II-CAS 140651-18-9-Calbiochem
4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H10N6O |
| Molecular weight | 218.22 |
| General description【一般描述】 | A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Cdk9 Reversible: no Product competes with ATP. Target IC50: 350 nM, using Cdk9/T1 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Other Notes【其他说明】 | Krystof, V., et al. 2006. J. Med. Chem.49, 6500. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | orange |
| solubility【溶解性】 | DMSO: 10 mg/mL ethanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
