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Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem
| 产品编号： | 4083763 |
| 规格： | The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 141992-47-4 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
141992-47-4
Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem
1,4-Dimethoxyacridine-9(10H)-thione
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H13NO2S |
| Molecular weight | 271.33 |
| MDL number | MFCD08276925 |
| General description【一般描述】 | A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM). A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target CDK4/D1 Target IC50: 200 nM against CDK4/D1 Product does not compete with ATP. Cell permeable: no Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Kubo, A., et al. 1999. Clin. Cancer Res.5, 4279. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | brown |
| solubility【溶解性】 | ethanol: 2.5 mg/mL DMSO: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19) |
| InChI key | KFAKESMKRPNZTM-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
