SKF-97541-CAS 127729-35-5-Calbiochem

C₄H₁₂NO₂P

137.12

A highly potent agonist of GABA_B receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC₅₀ = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.
A highly potent agonist of GABA_B receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC₅₀ = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Primary Target
GABA_B

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Kaye, A.D., et al. 2004. Anesth. Analg.99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.

Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

≥98% (TLC)

100

solid

Calbiochem^®

OK to freeze
protect from light

white

water: 100 mM

2-8℃

1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1

NHVRIDDXGZPJTJ-UHFFFAOYSA-O

Packaged under inert gas

11 - Combustible Solids

WGK 3