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Mitochondrial Pyruvate Carrier Inhibitor, UK5099-CAS 56396-35-1-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083372 | 5 MG | 1470 | |||
| 4083372 | 25 MG | 3660 |
产品别名
56396-35-1
Mitochondrial Pyruvate Carrier Inhibitor, UK5099-CAS 56396-35-1-Calbiochem
( E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, ( E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H12N2O2 |
| Molecular weight | 288.30 |
| MDL number | MFCD19443867 |
| General description【一般描述】 | A cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target mitochondria Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C. Use only fresh DMSO for reconstitution. |
| Other Notes【其他说明】 | Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA110, 5422. Bricker, D.K., et al. 2012. Science337, 96. Herzig, S., et al. 2012. Science337, 93. Hinoi, E., et al. 2006. Mol. Pharmacol.70, 925. Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta1707, 221. Halestrap, A.P. 1978. Biochem. J.172, 377. Halestrap, A.P. 1975. Biochem. J.145, 85. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Assay【测定】 | ≥99% (HPLC) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | bright yellow |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+ |
| InChI key | BIZNHCWFGNKBBZ-JLHYYAGUSA-N |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
