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Anti-ROKα/ROCK-II Antibody, clone A9W4, rabbit monoclonal

产品编号:4082526
规格:culture supernatant, clone A9W4, from rabbit
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4082526200 μL5850
产品别名

Anti-ROKα/ROCK-II Antibody, clone A9W4, rabbit monoclonal

RhoA-binding kinase 2, Rho-associated, coiled-coil containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, p150 ROK-alpha, p164 ROCK-2, ROCK-II, ROKalpha, Rock2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Rho-Associated Kinase (Rho-Kinase or ROK) has been classified into two isoforms: ROKα/ROCK-II and ROKβ/ROCK-I. These large cellular proteins (150-160 kDa), have been reported to be involved in the formation of stress fibers, focal adhesions and cardiac hypertonic responses. Current research suggests that ROK of smooth muscle may be involved in the contractile process via phosphorylation of MYPT1 and Myosin.
Specificity【特异性】
Recognizes ROKα/ROCK-II, Mr 150 kDa. Does not recognize ROKβ/ROCK-I. A non-specific band may also be detected, Mr 80 kDa.
Predicted to cross-react with mouse and bovine based on sequence homology.
Immunogen【免疫原】
6His-tagged fusion protein corresponding to residues 2-543 of rat ROKα/ROCK-II.
Application【应用】
Detect ROKα/ROCK-II using this Anti-ROKα/ROCK-II Antibody, clone A9W4 validated for use in IP & WB.
Research Sub Category
Cytoskeletal Signaling
Research Category
Signaling
Immunoprecipitation:
4 μL of a previous lot immunoprecipitated ROKα/ROCK-II from 500 μg of PC-12 lysate.
Quality【质量】
Routinely evaluated by Western BLot on RIPA lysates from PC-12 cells.

Western Blot Analysis: A 1:500-1:5000 dilution of this antibody detected ROKα/ROCK-II in RIPA lysates from PC-12 cells.
Linkage【联系】
Replaces: 05-841
Physical form【外形】
Cultured supernatant containing 0.05% sodium azide.
Analysis Note【分析说明】
Control
RIPA lysates from PC-12 cells
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
culture supernatant
antibody product type
primary antibodies
clone【克隆】
A9W4, monoclonal
species reactivity
mouse, human, bovine, rat
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NM_013022
UniProt accession no.【UniProt登记号】
Q62868
shipped in【运输】
dry ice
产品说明
Target description【目标描述】
150 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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