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Anti-PTEN Antibody, clone 6H2.1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration. |
Specificity【特异性】 | recognizes PTEN |
Immunogen【免疫原】 | Epitope: C-terminal region C-terminal 100 amino acids of PTEN |
Application【应用】 | Anti-PTEN Antibody, clone 6H2.1 detects level of PTEN & has been published & validated for use in WB, IP, IH(P). Research Category Signaling Research Sub Category PI3K, Akt, & mTOR Signaling |
Quality【质量】 | routinely evaluated on HeLa cell lysate |
Linkage【联系】 | Replaces: 07-016 |
Physical form【外形】 | Purified mouse IgG in storage buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4, with 0.05% sodium azide. Format: Purified Protein G Purified |
Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 6H2.1, monoclonal |
species reactivity | mouse, human, rat |
manufacturer/tradename | Upstate® |
technique(s) | immunohistochemistry: suitable (paraffin) immunoprecipitation (IP): suitable western blot: suitable |
isotype【同位素/亚型】 | IgG |
NCBI accession no.【NCBI登记号】 | NP_000305.3 |
UniProt accession no.【UniProt登记号】 | O08586 P60484 |
shipped in【运输】 | dry ice |
Gene Information | human ... PTEN(5728), TEP1(7011) |
产品说明
Target description【目标描述】 | 55 kDa |
Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |