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Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

产品编号:4082513
规格:culture supernatant, clone MC27, Upstate®
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4082513100 μL5010
产品别名

Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

40S ribosomal protein S6, Phosphoprotein NP33, ribosomal protein S6

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
S6 (Ribosomal protein S6, RpS6, 40S ribosomal protein S6) is known to play a role in cell growth and proliferation. It lays downstream of both the PI3K/Akt/mTOR pathway as a substrate of p70 S6 kinase and the Ras/Erk pathway as a substrate of RSK. S6 is phosphorylated in response to stimulation by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. There are two major areas of S6 phosphorylation; Ser235/Ser236 that is known to be phosphorylated by both p70S6 Kinase as well as RSK as well as Ser240/244 which is thought to only be phosphorylated by p70S6K.
Specificity【特异性】
Broad species cross-reactivity predicted, due to sequence homology.
Recognizes ribosomal protein S6 only when phosphorylated on Ser235.
Immunogen【免疫原】
Synthetic peptide containing the sequence …RRL[pS]SL… in which pS corresponds to phospho-serine at residue 235 of human ribosomal protein S6. The immunizing sequence is identical in mouse, rat, chicken and Xenopus.
Epitope: Phosphorylated Ser235
Application【应用】
Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27 is an antibody against phospho-Ribosomal Protein S6 (Ser235) for use in WB.
Western Blot Analysis:
A 1:500-1:2,000 dilution of this lot detected phosphorylated ribosomal protein S6 in lysates from serum stimulated 3T3 cells.
Research Sub Category
PI3K, Akt, & mTOR Signaling
Research Category
Signaling

Apoptosis & Cancer
Quality【质量】
Routinely evaluated by western blot on serum stimulated 3T3 cell lysate.
Physical form【外形】
Cultured supernatant with 0.05% sodium azide.
Analysis Note【分析说明】
Control
Serum stimulated 3T3 cell lysate.
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
culture supernatant
antibody product type
primary antibodies
clone【克隆】
MC27, monoclonal
species reactivity
human, rat, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NM_001010.2
UniProt accession no.【UniProt登记号】
P62753
shipped in【运输】
dry ice
Gene Information
human ... RPS6(6194)
产品说明
Target description【目标描述】
~30 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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