Anti-Lyn Antibody, clone 10A6.2

32160702

NA.41

Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.

Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).

KLH conjugated linear peptide corresponding to the C-terminus of Lyn.

Western Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
Anti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB.

Routinely evaluated by western blot on A431 cell lysate.

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

100

mouse

ascites fluid

primary antibodies

10A6.2, monoclonal

human

mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), rat (based on 100% sequence homology)

Upstate^®

western blot: suitable

IgG1κ

NP_001104567

Q6NUK7

dry ice

58 kDa

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12 - Non Combustible Liquids

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