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Anti-IRS1 Antibody, clone AW58, rabbit monoclonal

产品编号:4082498
规格:culture supernatant, clone AW58, Upstate®
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4082498100 μL6020
产品别名

Anti-IRS1 Antibody, clone AW58, rabbit monoclonal

insulin receptor substrate 1

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Insulin Receptor substrate proteins are the effectors of both Insulin and IGF-initiated signaling. They share PH and PTB domains near their n-termini, and multiple Tyr phosphorylation motifs in their c-terminal regions. Proteins which bind to tyrosine-phosphorylated IRS-proteins include PI3 Kinase p85, GRB2, SHP2, Nck, Crk, and Fyn. IRS1 appears to be principally involved in IGF-signaling and cytoskeletal growth. IRS2 appears to be the critical mediator of Insulin signaling, as genetic ablation results in type II diabetes. IRS3 is expressed primarily in adipocytes and is an unusually potent activator of PI3 Kinase. IRS4 lacks the tyrosine residues which in the other IRS-proteins binds to SHP2.
Specificity【特异性】
IRS1
Immunogen【免疫原】
Peptide corresponding to carboxy-terminal 14 amino acids (C-YASINFQKQPEDRQ) of rat liver IRS1
Application【应用】
Research Category
Signaling
Anti-IRS1 Antibody, clone AW58 detects level of IRS1 & has been published & validated for use in IP & WB.
Immunoblot Analysis: 1:1,000 to 1:4,000 dilutions of this lot detected IRS1 in RIPA lysates from 3T3/A31 mouse fibroblasts.

Immunoprecipitation: 5-10μl of this lot immunoprecipitated IRS1 from 500μg of 3T3/A31 RIPA lysate.


Research Sub Category
Insulin/Energy Signaling
Quality【质量】
routinely evaluated by immunoblot on in RIPA lysates from 3T3/A31 mouse fibroblasts
Linkage【联系】
Replaces: 05-784
Physical form【外形】
Cultured supernantant in 0.05% sodium azide
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
culture supernatant
antibody product type
primary antibodies
clone【克隆】
AW58, monoclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NM_005544
UniProt accession no.【UniProt登记号】
P35568
shipped in【运输】
dry ice
Gene Information
human ... IRS1(3667)
产品说明
Target description【目标描述】
Mr ~145-165kDa
Storage and Stability【储存及稳定性】
1 year at -20°C from date of shipment
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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