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SMCTM Human Interleukin 6 (IL-6) High Sensitivity Immunoassay Kit
产品编号: | 4082219 |
规格: | The sensitivity of the Single Molecule Counting (SMCTM) technology gives the SMC |
包装规格: | 96 well assay |
产品类别: | 进口试剂 |
品牌: | Millipore |
优惠价: | 立即咨询 |
基本信息
eCl@ss | 32161000 |
General description【一般描述】 | Interleukin 6 (IL-6) is secreted by T cells and macrophages and acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Some of its functions include the stimulation of the immune response during infection, induction of fever in autoimmune, infectious and non-infectious diseases, the stimulation of acute phase reactions, differentiation of T cells, proliferation and differentiation of B-cells, the development of blood cells as well as the activation of osteoclasts and osteoporosis and the secretion of vascular endothelium growth factor (VEFG) to increase blood vessel growth and vascular permeability in inflammation. It is important for a short-term defense against infection, injury and inflammation however dysregulation of IL-6 results in disease. IL-6 is important in the study of diseases such as diabetes, lupus, multiple myeloma, rheumatoid arthritis and some cancers such as prostate and pancreatic cancer. Conversely, deficiency of IL-6 can have an effect on immune activation and IgA antibodies while overexpression of IL-6 can result in an immunological imbalance leading to an autoimmune pathology. |
Specificity【特异性】 | Although IL-6 was detectable in non-human primate (rhesus macaque and cynomolgus monkey) samples, the assay has not been validated for these species. |
Application【应用】 | This new streamline kit has been improved with the following features while the kit performance is consistent with the legacy IL-6 kit, #03-0089-01: • Improved options for sample prep and incubation • Lyophilization of the standard provides the kit at one storage condition • Overnight incubation can be used • Increased reagent volumes to accommodate automation • Validated to run on both SMCxPRO® and Erenna Research Sub Category Inflammatory Disease Immune Response Autoimmune disease The sensitivity of the Single Molecule Counting (SMC™) technology gives the SMC Research Category Inflammation & Immunology |
Components【组分】 | Assay Buffer Human IL-6 Beads Standard Diluent Human IL-6 Detection Antibody Human IL-6 Standard 10X Wash Buffer Buffer D Elution Buffer B |
Specifications【产品规格】 | Minimum of 5 samples spiked with average recovery of 107% with a range of 90-114%. |
Legal Information【法律信息】 | SMC is a trademark of Singulex SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
species reactivity | human |
manufacturer/tradename | SMC™ |
assay range | sensitivity: 0.08 pg/mL (lower limit of quantification) inter-assay cv: <20% intra-assay cv: <15% (Intra-assay CV n=20; Inter-assay n=6) |
technique(s) | ELISA: suitable single molecule counting: suitable |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |