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UBE2K human

产品编号:4082170
规格:≥95% (SDS-PAGE)
包装规格:3 NMOL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40821703 NMOL5900
产品别名

UBE2K human

Ubiquitin-conjugating enzyme E2-25K kDa

LIG

HYPG

Huntington interacting protein 2

HIP2

基本信息
NACRES
NA.32
General description【一般描述】
UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer′s disease, Huntington′s disease and antigen processing through its interaction with amyloid-?, Huntington, and MHC-heavy chain proteins.
Physical form【外形】
75 μL of a 40 μM solution (3 nmoles) in TBS.
Preparation Note【制备说明】
Centrifuge the vial prior to opening.
产品性质
biological source【生物来源】
human
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
liquid
mol wt【分子量】
22.406 kDa
packaging【包装】
pkg of 3 nmol
NCBI accession no.【NCBI登记号】
P61086
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... UBE2K(3093)
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315 - H319
Precautionary Statements
P305 + P351 + P338
Hazard Classifications【危险分类】
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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