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Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem

产品编号:4081630
规格:A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 μM for HDAC1).
CAS NO:1069-66-5
包装规格:5 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40816305 G1190
产品别名

1069-66-5

Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem

2-Propylpentanoic Acid, Na

基本信息
Empirical Formula【经验(实验)分子式】
C8H15NaO2
Molecular weight
166.19
MDL number
MFCD00078604
NACRES
NA.77
General description【一般描述】
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
HDAC1
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Other Notes【其他说明】
Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
potency【效能】
400 μM IC50
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
color【颜色】
white
solubility【溶解性】
water: 50 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
packaging【包装】
5 g in Plastic ampoule
Packaged under inert gas
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Warning
Hazard Statements
H302 - H361d
Precautionary Statements
P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Hazard Classifications【危险分类】
Acute Tox. 4 Oral - Repr. 2
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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