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人类BNDF脑源性营养因子配体ELISA试剂盒
Human Fas Ligand ELISA Kit
产品编号: | 4081612 |
规格: | for serum, plasma, and cell culture supernatants |
包装规格: | 1 KIT |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
人类BNDF脑源性营养因子配体ELISA试剂盒
Human Fas Ligand ELISA Kit
FasL
基本信息
NACRES | NA.32 |
General description【一般描述】 | The Human Fas Ligand ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Fas Ligand in serum, plasma, cell culture supernatants and urine. |
Immunogen【免疫原】 | Recombinant Human Fas Ligand |
Application【应用】 | 请参考Protocol了解详情。 |
Biochem/physiol Actions【生化/生理作用】 | Binding of Fas Ligand (FasL) to Fas receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activate B cells which leads to down-regulation of the immune response. The mechanism of Fas induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD (Fas-associated protein with death domain) followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to eventual cell death. FasL is also involved in AGE (advanced glycation end-product)-mediated apoptosis in human retinal ARPE-19 cells, suggesting its role in diabetic retinopathy. Changes in the activity of FasL suppress normal apoptosis, leading to abnormal survival and growth of tumor cells. Mutations in the FasL gene causes autoimmune lymphoproliferative syndrome (ALPS). |
Other Notes【其他说明】 | A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number. |
Components【组分】 | 组份可单独销售 RABELADA ELISA 1X Assay/Sample Diluent Buffer A (Item D1) RABELADB ELISA 5X Assay/Sample Diluent Buffer B (Item E1) RABSTOP3 ELISA Stop Solution (Item I) RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H) RABWASH4 20X Wash Buffer (Item B) |
产品性质
species reactivity | human |
packaging【包装】 | kit of 96 wells (12 strips x 8 wells) |
technique(s) | ELISA: suitable capture ELISA: suitable |
input | sample type plasma sample type cell culture supernatant(s) sample type serum |
assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 2 pg/mL standard curve range: 1.37-1000 pg/mL |
Detection Method | colorimetric |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... FASLG(356) |
安全信息
Pictograms【象形图】 | GHS05 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H290 |
Precautionary Statements | P234 - P390 |
Hazard Classifications【危险分类】 | Met. Corr. 1 |
Storage Class Code【储存分类代码】 | 8A - Combustible, corrosive hazardous materials |
WGK | WGK 3 |