N^G,N^G-Dimethyl-L-arginine, Dihydrochloride-CAS 65005-57-4-Calbiochem

C₈H₁₈N₄O₂ · 2HCl

275.18

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.
Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Cell permeable: yes
Primary Target
NOS in vitro
Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro
Product does not compete with ATP.
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

amorphous solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: 50 mg/mL

wet ice

−20℃

25 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1