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InSolution AMPK 抑制剂，化合物 C·2HCl-CAS 866405-64-3-Calbiochem
InSolution AMPK Inhibitor, Compound C·2HCl-CAS 866405-64-3-Calbiochem
| 产品编号： | 4080421 |
| 规格： | The InSolution |
| CAS NO： | 866405-64-3 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4080421 | 2 MG | 2700 |
产品别名
866405-64-3
InSolution
InSolution AMPK Inhibitor, Compound C·2HCl-CAS 866405-64-3-Calbiochem
6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O, AMPK Inhibitor I
AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H25N5O |
| Molecular weight | 399.49 |
| MDL number | MFCD08705402 |
| General description【一般描述】 | A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available. |
| Physical form【外形】 | A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O. |
| Reconstitution【重悬】 | Following intial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33. Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970. Lee, M., et al. 2003. J. Biol. Chem.278, 39653. Inoki, K., et al. 2003. Cell115, 577. Fryer, L.G., 2002. FEBS Lett.531, 189. Zhou, G., et al. 2001. J. Clin. Invest.108, 1167. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
