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D,L-萝卜硫素-CAS 4478-93-7-Calbiochem
D,L-Sulforaphane-CAS 4478-93-7-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4076742 | 25 MG | 3460 |
产品别名
4478-93-7
D,L-萝卜硫素-CAS 4478-93-7-Calbiochem
D,L-Sulforaphane-CAS 4478-93-7-Calbiochem
1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
基本信息
| Empirical Formula【经验(实验)分子式】 | C6H11NOS2 |
| Molecular weight | 177.29 |
| MDL number | MFCD00198068 |
| NACRES | NA.77 |
| General description【一般描述】 | An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway. An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Cell permeable: no Primary Target Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C. |
| Other Notes【其他说明】 | Gamet-Payrastre, L., et al. 2000. Cancer Res.60, 1426. Yu, R., et al. 2000. J. Biol. Chem.275, 2322. Yu, R., et al. 1999. J. Biol. Chem.274, 27545. Barcelo, S., et al. 1998. Mutat. Res.402, 111. Maheo, K., et al. 1997. Cancer Res.57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 2399. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (UPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | slight yellow |
| solubility【溶解性】 | ethanol: 10 mg/mL DMSO: 20 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3 |
| InChI key | SUVMJBTUFCVSAD-UHFFFAOYSA-N |
| packaging【包装】 | 25 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
