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Diphenyleneiodonium Chloride-CAS 4673-26-1-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4076718 | 10 MG | 1520 |
产品别名
4673-26-1
Diphenyleneiodonium Chloride-CAS 4673-26-1-Calbiochem
DPI
基本信息
Empirical Formula【经验(实验)分子式】 | C12H8ClI |
Molecular weight | 314.55 |
MDL number | MFCD00214165 |
General description【一般描述】 | A cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50 = 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system. A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target eNOS Product does not compete with ATP. Reversible: no Target IC50: 180 nM against endothelial nitric oxide synthase (eNOS) |
Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
Preparation Note【制备说明】 | Slight warming is required for complete solubility. |
Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Wang, Y.X., et al. 1995. Br. J. Pharmacol.114, 194. Majander, A., et al. 1994. J. Biol. Chem. 269, 21037. Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611. Wang, Y.X., et al. 1993. Br. J. Pharmacol.110, 1232. Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol.109, 1186. Stuehr, D.J., et al. 1991. FASEB J.5, 98. Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J.242, 103. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | crystalline solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 5 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 10 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |