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Tat-NR2B9c trifluoroacetate

产品编号:4076594
规格:≥95% (HPLC)
CAS NO:500992-11-0
包装规格:1 MG,5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40765941 MG968
40765945 MG3400
产品别名

500992-11-0

Tat-NR2B9c trifluoroacetate

NA-1, trifluoroacetate salt

YGRKKRRQRRR-KLSSIESDV, trifluoroacetate salt

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val, trifluoroacetate salt

基本信息
Empirical Formula【经验(实验)分子式】
C105H188N42O30 · xC2HF3O2
Molecular weight
2518.88 (free base basis)
Biochem/physiol Actions【生化/生理作用】
Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV that blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset).
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
powder
color【颜色】
white to off-white
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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