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Procathepsin K human
| 产品编号： | 4076535 |
| 规格： | recombinant, expressed in E. coli, ≥95% (SDS-PAGE) |
| 包装规格： | 50 μG，1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Procathepsin K human
CTSO3
CTSO
CTSK
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | 35.9 kDa |
| packaging【包装】 | pkg of 1 mg pkg of 50 μg |
| concentration【浓度】 | 1 mg/mL |
| UniProt accession no.【UniProt登记号】 | P43235 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... CATK(1513) |
基本信息
| General description【一般描述】 | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic. |
| Physical form【外形】 | 1 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0). |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
