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Mca-APK(Dnp)-OH trifluoroacetate
产品别名
Mca-APK(Dnp)-OH trifluoroacetate
Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl)
Mca-Ala-Pro-Lys(Dnp)-OH TFA salt
Mca-Ala-Pro-Lys(Dnp) TFA salt
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H36N6O12 |
| Molecular weight | 696.66 |
| Biochem/physiol Actions【生化/生理作用】 | Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | film or powder |
| color【颜色】 | white to dark beige |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
