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Lomefloxacin Hydrochloride
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4076464 | 1 G | 523 | |||
| 4076464 | 10 G | 2880 |
产品别名
98079-52-8
Lomefloxacin Hydrochloride
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H19F2N3O3 · HCl |
| Molecular weight | 387.81 |
| MDL number | MFCD00214312 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278514 |
| NACRES | NA.85 |
| General description【一般描述】 | Chemical structure: fluoroquinolone |
| Application【应用】 | Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria. |
| Biochem/physiol Actions【生化/生理作用】 | Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | synthetic |
| color【颜色】 | white to off-white |
| Mode of action【作用机制】 | DNA synthesis | interferes enzyme | inhibits |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-negative bacteria Gram-positive bacteria |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 |
| InChI | 1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H |
| InChI key | KXEBLAPZMOQCKO-UHFFFAOYSA-N |
| packaging【包装】 | 1, 10 g in poly bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
