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S14161

产品编号:4075981
规格:≥98% (HPLC)
CAS NO:883046-50-2
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40759811 MG958
产品别名

883046-50-2

S14161

Pichromene

8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran

8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C17H14FNO4
Molecular weight
315.30
MDL number
MFCD00112055
PubChem Substance ID【PubChem化学物质编号】
329825969
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
protect from light
color【颜色】
white to beige
storage temp.【储存温度】
−20℃
SMILES string
FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
InChI
1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
InChI key
BFZXDHIUPNWOMT-UHFFFAOYSA-N
packaging【包装】
1, 5 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315
Hazard Classifications【危险分类】
Skin Irrit. 2
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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