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LY2112688 trifluoroacetate

产品编号:4075941
规格:≥95% (HPLC)
CAS NO:819048-44-7
包装规格:1 MG,5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40759411 MG1160
40759415 MG4250
产品别名

819048-44-7

LY2112688 trifluoroacetate

LY-2112688 TFA salt

Ac-D-Arg-c(Cys-Glu-His-D-Phe-Arg-Trp-Cys)-NH2, trifluoroacetate salt

Ac-D-Arg-cyclo[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH2, trifluoroacetate salt

Ac-rCEHfRWC-NH2, TFA (D-amino acids in lower case; C2→C8 disulfide)

Acetyl-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2, trifluoroacetate salt (Cys2→Cys8 disulfide)

LY 2112688 TFA salt

基本信息
Empirical Formula【经验(实验)分子式】
C51H70N18O11S2 · xC2HF3O2
Molecular weight
1175.35 (free base basis)
Biochem/physiol Actions【生化/生理作用】
LY2112688 is a beta-melanocyte-stimulating hormone (β-MSH)-derived peptide that acts as a high-affinity, potent and selective melanocortin receptor 4 (MC-4, MC-4R, MC4-R, MC4R) agonist (human/rat MC-4 Ki = 0.55/0.39 nM; human MC-1/3/5 Ki = 16.78/56.79/>500 nM). LY2112688 selectively induces MC-4-mediated cAMP release (MC-4/3 EC50 = 0.25 nM/1.61 nM, MC-4/3 Emax = 94.5%/84.1% of NDP-α-MSH Emax using HEK293 expressing respective human receptors) and exhibits in vivo efficacy in reducing daily food intake and promoting weight loss among diet-induced obese rats (75 & 299 nmol/kg/day s.c.).
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
lyophilized powder
color【颜色】
white to off-white
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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