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Inosine Monophosphate Dehydrogenase Type II human

产品编号:4075889
规格:recombinant, expressed in E. coli
包装规格:0.125 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40758890.125 ML9420
产品别名

Inosine Monophosphate Dehydrogenase Type II human

IMPDH II

IMP:NAD oxidoreductase

基本信息
Enzyme Commission (EC) Number【酶学委员会(EC)编号】
1.1.1.205 ( BRENDA | IUBMB )
MDL number
MFCD04975063
NACRES
NA.54
General description【一般描述】
Inosine Monophosphate Dehydrogenase Type II (IMPDH2) is a ubiquitously expressed dominant isoform during developmental stages. IMPDH2 gene is mapped to human chromosome 3p21.31.
Application【应用】
Inosine Monophosphate Dehydrogenase Type II human has been used to test the inhibitory effect on vacor adenine dinucleotide (VAD) on its dehydrogenase activity.
Biochem/physiol Actions【生化/生理作用】
Inosine Monophosphate Dehydrogenase Type II (IMPDH2) binds to adenosine triphosphate (ATP) and guanosine triphosphate (GTP). It catalyzes the formation of xanthosine monophosphate from inosine monophosphate in the presence of nicotinamide adenine dinucleotide (NAD). IMPDH2 elevated levels in tumors are correlated to its rate-limiting activity in guanosine monophosphate (GMP) synthesis. High levels of IMPDH2 is implicated in glioblastoma (GBM). It is regarded as a potential therapeutic target against tumors, antiviral, and immunosuppression-related pathologies.
Type II is the predominant IMPDH isoform and is specifically linked to a wide range of cancers and lymphocyte proliferation.
Unit Definition【单位定义】
One unit will produce 1.0 μ mole of XMP from IMP with corresponding reduction of β-NAD per minute at pH 8.0 at 25 ℃.
Physical form【外形】
Solution in 20 mM Tris-HCl, pH 8.0, containing 0.5 mM EDTA and 1 mM DTT.
产品性质
Quality Level【质量水平】
200
recombinant【重组】
expressed in E. coli
form【形式】
solution
Specific Activity
≥0.05 units/mg protein
mol wt【分子量】
~55 kDa
packaging【包装】
vial of ≥0.002 unit
UniProt accession no.【UniProt登记号】
P12268
relevant disease(s)【相关疾病】
cancer
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... IMPDH2(3615)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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