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Elocalcitol
产品别名
199798-84-0
Elocalcitol
Ro 26-9228
BXL-628
(1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylenecyclohexanol
BXL 628
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H43FO2 |
| Molecular weight | 442.65 |
| MDL number | MFCD09954119 |
| Biochem/physiol Actions【生化/生理作用】 | Elocalcitol (BX-L628) is an analog of Vitamin D3 that acts as an agonist at vitamin D VDR receptors. It has been shown to inhibit prostate cell growth and RhoA/Rho-kinase signaling. Elocalcitol (BXL-628) downregulated the expression of active RhoA and ROCK activity induced by high glucose and was shown to have renal protective effects. Elocalcitol is a Vitamin D receptor (VDR) agonist and is an analog of calcitriol. Elocalcitol possesses anti-inflammatory and anti- proliferative properties. It regulates cell apoptosis and cell proliferation by binding to Vitamin D receptors (VDR). It shows a therapeutic effect on people suffering from Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D +97 to +107°, c = c=1 in methanol |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
