Cyrene^TM γ-Valerolactone Blend

C₆H₈O₃

128.13

Cyrene^™ γ-Valerolactone Blend is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields.

This Cyrene^™ blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene^™ nor γ-Valerolactone have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents.

This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon.

This cosolvent solution has been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions, such as:

• HATU Amide Coupling - Replacement for DMF in amide and dipeptide coupling reactions (eq. 1)
• Suzuki-Miyaura coupling reaction (eq. 2)
• Sonogashira coupling reaction (eq. 3)

To see other BioRenewable or Greener Solvents

CYRENE is a trademark of Circa Group Pvt Ltd

liquid

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

1.141 g/mL

Aligned

GHS07

Warning

H319

P264 - P280 - P305 + P351 + P338 - P337 + P313

Eye Irrit. 2

10 - Combustible liquids

WGK 2