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Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free-CAS 9087-70-1-Calbiochem

产品编号:4075259
规格:recombinant, expressed in Nicotiana, heat and acid-stable competitive, reversible inhibitor of serine proteases
CAS NO:9087-70-1
包装规格:1 MG,5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40752591 MG1300
40752595 MG2180
407525925 MG3600
产品别名

9087-70-1

Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free-CAS 9087-70-1-Calbiochem

Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor

基本信息
Empirical Formula【经验(实验)分子式】
C284H432N84O79S7
Molecular weight
6511.44
MDL number
MFCD00130541
EC Index Number【EC索引号】
2329949
General description【一般描述】
Recombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
Biochem/physiol Actions【生化/生理作用】
Product does not compete with ATP.
Reversible: yes
Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
Primary Target
chymotrypsin
Cell permeable: no
Warning【警告】
Toxicity: Standard Handling (A)
Unit Definition【单位定义】
One TIU (Trypsin Inhibitory Unit) is defined as the amount of aprotinin or product or inhibitor that will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1 µmol BAPNA per min at 25°C, pH 7.8.
Physical form【外形】
Contains no animal-derived components.
Other Notes【其他说明】
Deutscher, M.P., 1990. Methods Enzymol.182, 83.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
200
recombinant【重组】
expressed in Nicotiana
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
powder
Specific Activity
>5 TIU/mg protein
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
white to yellow
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
packaging【包装】
25 mg in Glass bottle
1, 5 mg in Plastic ampoule
Please refer to vial label for lot-specific concentration.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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