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Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free-CAS 9087-70-1-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4075259 | 1 MG | 1300 | |||
4075259 | 5 MG | 2180 | |||
4075259 | 25 MG | 3600 |
产品别名
9087-70-1
Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free-CAS 9087-70-1-Calbiochem
Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
基本信息
Empirical Formula【经验(实验)分子式】 | C284H432N84O79S7 |
Molecular weight | 6511.44 |
MDL number | MFCD00130541 |
EC Index Number【EC索引号】 | 2329949 |
General description【一般描述】 | Recombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage. |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: yes Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively Primary Target chymotrypsin Cell permeable: no |
Warning【警告】 | Toxicity: Standard Handling (A) |
Unit Definition【单位定义】 | One TIU (Trypsin Inhibitory Unit) is defined as the amount of aprotinin or product or inhibitor that will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1 µmol BAPNA per min at 25°C, pH 7.8. |
Physical form【外形】 | Contains no animal-derived components. |
Other Notes【其他说明】 | Deutscher, M.P., 1990. Methods Enzymol.182, 83. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 200 |
recombinant【重组】 | expressed in Nicotiana |
Assay【测定】 | ≥95% (SDS-PAGE) |
form【形式】 | powder |
Specific Activity | >5 TIU/mg protein |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze |
color【颜色】 | white to yellow |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 25 mg in Glass bottle 1, 5 mg in Plastic ampoule Please refer to vial label for lot-specific concentration. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | nwg |