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Eg5 Inhibitor III, Dimethylenastron-CAS 863774-58-7-Calbiochem
产品编号: | 4075254 |
规格: | The Eg5 Inhibitor III, Dimethylenastron, also referenced under CAS 863774-58-7, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Membrane applications. |
CAS NO: | 863774-58-7 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4075254 | 5 MG | 5510 |
产品别名
863774-58-7
Eg5 Inhibitor III, Dimethylenastron-CAS 863774-58-7-Calbiochem
7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
基本信息
Empirical Formula【经验(实验)分子式】 | C16H18N2O2S |
Molecular weight | 302.39 |
General description【一般描述】 | A cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC50 = 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells. A cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC50 = 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 200 nM inhibiting the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 Primary Target Microtubule-stimulated ATPase activity of the mitotic motor Product does not compete with ATP. Reversible: yes |
Warning【警告】 | Toxicity: Harmful (C) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Other Notes【其他说明】 | Liu, M., et al. 2006. J. Biol Chem.in press. Gartner, M., et al. 2005. Chembiochem6, 1173. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | light yellow |
solubility【溶解性】 | DMSO: 10 mg/mL methanol: 5 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 1, 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |