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铁蛋白 来源于人类肝脏

Ferritin from human liver
产品编号:4074597
规格:Type IV, 10 μg/mL
CAS NO:9007-73-2
包装规格:1 VIAL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40745971 VIAL3490
产品别名

9007-73-2

铁蛋白 来源于人类肝脏

Ferritin from human liver

基本信息
MDL number
MFCD00081593
NACRES
NA.61
General description【一般描述】
Ferritin comprises 24-subunit and belongs to the ferritin-like diiron-carboxylate protein superfamily. Ferritin exists as heavy (H) and light (L) subunits. Liver ferritin is majorly L subunit and the spleen has the H submit. The L subunit is mapped to human chromosome 9q13.33 and the H subunit 11q12.3.
Application【应用】
Ferritin from human liver has been used as model protein in size-exclusion high-performance liquid chromatography technique and for synthetic nanopore translocation studies. It has also been used to test its effect on the susceptibility of shrimp (Litopenaeus vannamei) to the white spot syndrome virus.
Biochem/physiol Actions【生化/生理作用】
A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.
Ferritins are part of the host defense system and play a role in response to viral infection in animals. The abnormal levels of ferritin are correlated to many tumors associated with the prostate, breast and brain. High levels of ferritin are implicated in inflammation and macrophage activation syndrome (MAS). Mutations in the light subunit chain can lead to the neurodegenerative disease, hereditary ferritinopathy.
Physical form【外形】
Solution in 10 mM Tris, 150 mM NaCl, pH 8.0, and 0.1% sodium azide.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
human liver
sterility【无菌性】
0.2 μm filtered
type【类型】
Type IV
Assay【测定】
≥95% (SDS-GE)
form【形式】
liquid
mol wt【分子量】
H subunit ~21 kDa
L subunit ~19 kDa
~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)
packaging【包装】
vial of 2 μg
concentration【浓度】
10 μg/mL
UniProt accession no.【UniProt登记号】
P02792
P02794
Q8N4E7
storage temp.【储存温度】
2-8℃
Gene Information
human ... FTH1(2495), FTL(2512), FTMT(94033)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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