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Quinone Oxidoreductase 2 (NQO2) human
产品编号: | 4073910 |
规格: | recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein |
包装规格: | 1 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Quinone Oxidoreductase 2 (NQO2) human
NQO2 human
NRH nitroreductase human
NRH quinone reductase human
基本信息
MDL number | MFCD03458332 |
NACRES | NA.54 |
Application【应用】 | Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954. The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity. |
Biochem/physiol Actions【生化/生理作用】 | Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway. Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor. |
Unit Definition【单位定义】 | One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 ℃. |
Physical form【外形】 | contains 10% PBS buffer salts |
产品性质
Quality Level【质量水平】 | 200 |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥90% (SDS-PAGE) |
form【形式】 | lyophilized powder (one vial contains one mg protein) |
Specific Activity | ≥100 units/mg protein |
UniProt accession no.【UniProt登记号】 | P16083 |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... NQO2(4835) |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |