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Quinone Oxidoreductase 2 (NQO2) human

产品编号:4073910
规格:recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40739101 MG6170
产品别名

Quinone Oxidoreductase 2 (NQO2) human

NQO2 human

NRH nitroreductase human

NRH quinone reductase human

基本信息
MDL number
MFCD03458332
NACRES
NA.54
Application【应用】
Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.
Biochem/physiol Actions【生化/生理作用】
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.
Unit Definition【单位定义】
One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 ℃.
Physical form【外形】
contains 10% PBS buffer salts
产品性质
Quality Level【质量水平】
200
recombinant【重组】
expressed in E. coli
Assay【测定】
≥90% (SDS-PAGE)
form【形式】
lyophilized powder (one vial contains one mg protein)
Specific Activity
≥100 units/mg protein
UniProt accession no.【UniProt登记号】
P16083
storage temp.【储存温度】
−20℃
Gene Information
human ... NQO2(4835)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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