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盐酸氯胍
Proguanil hydrochloride
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4063834 | 1 G | 2630 |
产品别名
637-32-1
盐酸氯胍
Proguanil hydrochloride
Chlorguanide
N1-(4-Chlorophenyl)-N5-isopropylbiguanide
氯胍 盐酸盐
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H16ClN5·HCl |
| Molecular weight | 290.19 |
| EC number【EC 号】 | 211-283-7 |
| MDL number | MFCD01732193 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823569 |
| NACRES | NA.24 |
| General description【一般描述】 | Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Application【应用】 | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Proguanil hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography. |
| Biochem/physiol Actions【生化/生理作用】 | Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
| Analysis Note【分析说明】 | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Other Notes【其他说明】 | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Footnote【附注】 | To see an example of a Certificate of Analysis for this material enter LRAA7301 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
产品性质
| Quality Level【质量水平】 | 300 |
| grade【等级】 | certified reference material pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| packaging【包装】 | pkg of 1 g |
| technique(s) | HPLC: suitable gas chromatography (GC): suitable |
| application(s) | pharmaceutical (small molecule) |
| format【格式】 | neat |
| pharmacopeia traceability【药典可追溯性】 | traceable to BP 297 traceable to USP 1568040 |
| storage temp.【储存温度】 | 2-30℃ |
| SMILES string | Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 |
| InChI | 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H |
| InChI key | SARMGXPVOFNNNG-UHFFFAOYSA-N |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
