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Cyclin-Dependent Kinase 5 human
| 产品编号： | 4063741 |
| 规格： | recombinant, expressed in E. coli BL21, 50-100 units/μg protein |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD06201997 |
| NACRES | NA.54 |
| Application【应用】 | Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability. |
| Biochem/physiol Actions【生化/生理作用】 | CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29. |
| Unit Definition【单位定义】 | One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 ℃ at pH 7.4. |
| Physical form【外形】 | Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli BL21 |
| form【形式】 | solution |
| Specific Activity | 50-100 units/μg protein |
| packaging【包装】 | vial of 300 units |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
