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Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit
| 产品编号： | 4063706 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit
Anti-phospho-Rb (pSer811)
基本信息
| MDL number | MFCD06411917 |
| General description【一般描述】 | Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene. |
| Immunogen【免疫原】 | synthetic phosphopeptide derived from the region of human Rb that contains Ser811. |
| Biochem/physiol Actions【生化/生理作用】 | Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis. |
| Physical form【外形】 | Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase. |
| UniProt accession no.【UniProt登记号】 | P06400 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... RB1(5925) mouse ... Rb1(19645) rat ... Rb1(24708) |
