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Myeloperoxidase Inhibitor-I-CAS 5351-17-7-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061719 | 1 G | 1220 |
产品别名
5351-17-7
Myeloperoxidase Inhibitor-I-CAS 5351-17-7-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C7H9N3O |
| Molecular weight | 151.17 |
| MDL number | MFCD00007606 |
| General description【一般描述】 | A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells. A benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC50 = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC50 = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H2O2-treated HL-60 promyelocytic leukemia cells. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Target IC50: 300 nM against myeloperoxidase (MPO) Cell permeable: no Primary Target Myeloperoxidase |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Engelmann, I., et al. 2000. Redox Report5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem.275, 22461. Burner, U., et al. 1999. J. Biol. Chem.274, 9494. Kettle, A.J., et al. 1997. Biochem. J.321, 503. Kettle, A.J., et al. 1995. Biochem. J.308, 559. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | beige |
| solubility【溶解性】 | DMSO: 10 mg/mL dilute acid: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11) |
| InChI key | WPBZMCGPFHZRHJ-UHFFFAOYSA-N |
| packaging【包装】 | 1 g in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
